Description
Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase.
Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins.
SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase.
Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1.
Plays a protective role after myocardial infarction.
Induces down-regulation and internalization of ACKR3 expressed in various cells.
Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells